Therapeutic agent, method of treatment and method for predicting the severity of systemic inflammatory response syndrome (SIRS), diseases caused or accompanied by neutrophil activation

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United States of America Patent

PATENT NO 9696321
SERIAL NO

14995679

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Abstract

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The present invention provides a neutrophil activation regulator comprising a histidine-rich glycoprotein (HRG) for the treatment of systemic inflammatory response syndrome (SIRS), diseases caused by neutrophil activation and/or inflammatory diseases accompanied by neutrophil activation in a subject in need thereof. Further, the present invention provides methods for predicting the severity of systemic inflammatory response syndrome (SIRS), diseases caused by neutrophil activation and/or inflammatory diseases accompanied by neutrophil activation in a subject in need thereof, and methods for predicting the survival of a subject with systemic inflammatory response syndrome (SIRS), diseases caused by neutrophil activation and/or inflammatory diseases accompanied by neutrophil activation, that comprise determining the blood level of histidine-rich glycoprotein in the subject.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY1-1 TSUSHIMA-NAKA 1-CHOME OKAYAMA-SHI OKAYAMA 770-8530

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kuroda, Kosuke Okayama, JP 22 100
Liu, Keyue Okayama, JP 7 7
Mori, Shuji Okayama, JP 18 87
Morimatsu, Hiroshi Okayama, JP 1 1
Nishibori, Masahiro Okayama, JP 18 69
Sakaguchi, Masakiyo Okayama, JP 17 106
Takahashi, Hideo Okayama, JP 187 2129
Teshigawara, Kiyoshi Okayama, JP 2 2
Wake, Hidenori Okayama, JP 7 2

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