Binding domains directed against GPCR:G protein complexes and uses derived thereof

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United States of America Patent

PATENT NO 9695227
APP PUB NO 20140275487A1
SERIAL NO

14129100

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Abstract

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The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;THE REGENTS OF THE UNIVERSITY OF MICHIGAN;VIB VZW;VRIJE UNIVERSITEIT BRUSSEL;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITV

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Granier, Sebastian Menlo Park, US 1 0
Kobilka, Brian Palo Alto, US 51 242
Laeremans, Toon Dworp, BE 44 259
Pardon, Els Lubbeek, BE 37 110
Rasmussen, Søren Frederiksberg, DK 6 4
Steyaert, Jan Beersel, BE 42 116
Sunahara, Roger K Ann Arbor, US 10 72

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