Methods of predicting ancestral virus sequences and uses thereof
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United States of America Patent
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Jul 4, 2017
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app pub date -
Apr 11, 2016
filing date -
Oct 11, 2013
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Abstract
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
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