Fibrinogen preparations enriched in fibrinogen with an extended alpha chain
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United States of America Patent
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Jul 4, 2017
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app pub date -
Oct 7, 2015
filing date -
Jan 8, 2010
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Abstract
The present invention relates to fibrinogen preparations enriched in α-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of α-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by α-extended fibrinogen are improved. In addition, plasmin-mediated degradation of α-extended fibrinogen is reduced as compared to plasma derived fibrinogen.
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