Aspartyl-tRNA synthetase-Fc conjugates
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United States of America Patent
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Jun 27, 2017
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Nov 13, 2014
app pub date -
Dec 27, 2012
filing date -
Dec 29, 2011
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Abstract
The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.
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