Bi-specific affinity reagents for cell-lineage-specific TNF-alpha neutralization
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United States of America Patent
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Jun 27, 2017
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Oct 8, 2015
app pub date -
Oct 28, 2013
filing date -
Oct 26, 2012
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Abstract
The invention relates to isolated bispecific affinity reagents, such as antibodies or antibody fragments that bind TNFα and a marker molecule for macrophages and/or neutrophils. The affinity reagents of the invention enable pathogenic sub-populations of TNFα to be neutralized, while protective sub-populations of TNFα are not affected.
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