Dendritic cell vaccines for asparaginyl-β-hydroxylase expressing tumors
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United States of America Patent
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Jun 27, 2017
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Mar 31, 2011
app pub date -
Jul 23, 2010
filing date -
Jul 24, 2009
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Abstract
A vaccine containing AAH-loaded mature dendritic cells for treatment of AAH-expressing tumors in mammalian subjects. A method of producing primed dendritic cells is carried out by contacting isolated dendritic cells with an antigen such as AAH. Following the antigen-contacting step, the dendritic cells are contacted with a combination of cytokines such as GM-CSF and IFN-γ.
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