Use of NK-1 receptor antagonists for treating hypomagnesemia, neurogenic inflammation, and cardiac dysfunction associated with EGFR-blocking drugs
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United States of America Patent
Stats
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Jun 27, 2017
Grant Date -
Jan 19, 2017
app pub date -
Sep 28, 2016
filing date -
Jun 10, 2014
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present disclosure provides methods for alleviating or preventing the negative physiological side effects associated with the administration of EGFR blocking therapeutics. The disclosure provides, inter alia, methods for treating or preventing: hypomagnesemia, cardiac dysfunction, and skin lesions, which are induced by EGFR blocking drugs, by administering an NK-1 receptor antagonist.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
THE GEORGE WASHINGTON UNIVERSITY | 1922 F STREET NW WASHINGTON DC 20052 |
International Classification(s)

- 2016 Application Filing Year
- A61K Class
- 19101 Applications Filed
- 13019 Patents Issued To-Date
- 68.16 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Mak, Iu Tong | Gaithersburg, US | 2 | 4 |
# of filed Patents : 2 Total Citations : 4 | |||
Weglicki, William B | Potomac, US | 8 | 33 |
# of filed Patents : 8 Total Citations : 33 |
Cited Art Landscape
- No Cited Art to Display

Patent Citation Ranking
- 3 Citation Count
- A61K Class
- 45.09 % this patent is cited more than
- 8 Age
Forward Cite Landscape
- No Forward Cites to Display

Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Dec 27, 2024 |
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Dec 27, 2028 |
Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
---|---|---|---|
Dec 27, 2024 | MAFP | MAINTENANCE FEE PAYMENT | free format text: PAYMENT OF MAINTENANCE FEE, 8TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2552); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 8 |
Dec 28, 2020 | MAFP | MAINTENANCE FEE PAYMENT | free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 4 |
Jun 27, 2017 | I | Issuance | |
Jun 07, 2017 | STCF | INFORMATION ON STATUS: PATENT GRANT | free format text: PATENTED CASE |
Feb 01, 2017 | AS | ASSIGNMENT | free format text: CONFIRMATORY LICENSE;ASSIGNOR:GEORGE WASHINGTON UNIVERSITY;REEL/FRAME:041628/0147 Owner name: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF Effective Date: Feb 01, 2017 |
Jan 19, 2017 | P | Published | |
Sep 28, 2016 | F | Filing | |
Jul 08, 2015 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WEGLICKI, WILLIAM B.;MAK, IU TONG;REEL/FRAME:041657/0460 Owner name: THE GEORGE WASHINGTON UNIVERSITY, DISTRICT OF COLU Effective Date: Jul 08, 2015 |

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