Use of dianhydrogalactitol and analogs and derivatives thereof to treat glioblastoma multiforme
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United States of America Patent
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Jun 27, 2017
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app pub date -
Apr 4, 2014
filing date -
Jan 20, 2012
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Abstract
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.
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