Enhancement of transport of therapeutic molecules across the blood brain barrier
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United States of America Patent
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Jun 13, 2017
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Jul 30, 2015
app pub date -
Jan 10, 2013
filing date -
Jan 10, 2012
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Abstract
The invention is based, at least in part, on the finding that a dimeric version of a BBB-transmigrating antibody (e.g., the TMEM30A (CDC-50A) binding antibody, FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 VHH. The invention provides, inter alia, molecules that increase transport of pharmacologically active agents across the blood brain barrier, methods for increasing transport across the blood brain barrier, and methods of treatment of disorders or diseases having a neurological component.
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