Process for the preparation of abiraterone or abiraterone acetate
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United States of America Patent
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Jun 13, 2017
Grant Date -
Jun 16, 2016
app pub date -
Jul 23, 2014
filing date -
Jul 29, 2013
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Abstract
The present invention relates to a novel process for the synthesis of abiraterone and in particular abiraterone acetate, a compound of formula (I) reported below: having pharmacological activity suitable for slowing down the progression of advanced stage prostate cancer. The process is characterized by the fact that the intermediate triflation step is carried out on prasterone (DHEA) or its 3-acetate using Ar—N(OTf)2 as the triflation reagent, but where Ar is not phenyl, and by the fact that the base used in this step is an alkali metal alcoholate.
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