antagonists, preparation method and use thereof

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United States of America Patent

PATENT NO 9676772
SERIAL NO

14907050

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Abstract

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This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in schizophrenia, anxiety, depression, maniac depression, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, panic attacks, attention deficit hyperactivity disorder, attention deficit disorder, Parkinson's disease, Huntington's disease, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, obesity and type-2 diabetes, functional bowel disorder, Irritable Bowel Syndrome. The compounds have the general formula (XIV), wherein the symbols have the meanings given in the description.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 RUE MICHEL-ANGE PARIS 75016
UNIVERSITÉ DE MONTPELLIER163 RUE AUGUSTE BROUSSONNET MONTPELLIER 34090
UNIWERSYTET JAGIELLONSKICRACOW
INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUKSMETNA 12 KRAKOW

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bantreil, Xavier Aigues-vives, FR 2 1
Bojarski, Andrzej J Zabierzów, PL 3 1
Colacino, Evelina Montpellier, FR 2 1
Grychowska, Katarzyna Kraków, PL 2 1
Kos, Tomasz Kraków, PL 2 1
Lamaty, Frederic Montpellier, FR 2 1
Martinez, Jean Caux, FR 43 206
Partyka, Anna Kraków, PL 2 1
Pawlowski, Maciej Wieliczka, PL 7 3
Popik, Piotr Kraków, PL 2 1
Satala, Grzegorz Kraków, PL 3 1
Subra, Gilles Saint Gély du Fesc, FR 14 21
Wesolowska, Anna Kraków, PL 5 3
Zajdel, Pawel Kraków, PL 3 1

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