Methods for classifying pleural fluid

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United States of America Patent

PATENT NO 9675283
SERIAL NO

14334781

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods of classifying pleural fluid are disclosed. The methods typically include determining the level of indicator nanoparticles, such as lipids, particularly large lipids, in the pleural fluid of a subject. The level of lipids can be determined by nuclear magnetic resonance (NMR), such as proton NMR (1H-NMR) by measuring the NMR signal corresponding to methyl protons, methylene protons, methene protons, or combinations thereof. The level of large lipids in pleural fluid can be carried out in vitro on a sample of pleural fluid obtained from the subject or in vivo using magnetic resonance spectroscopy (MRS). The pleural fluid can be classified as exudate or transudate with a sensitivity, selectivity, or combination thereof of 85%, 90%, 95%, 99%, or higher, a selectivity of 85%, 90%, 95%, 99%. The method can be coupled with diagnosing and/or treating the subject with a disease, disorder, or condition.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF HONG KONGPOKFULAM ROAD HONG KONG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lam, Ching-Wan Kowloon, HK 2 1

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