Methods for reducing accumulation of lactate during culturing and method for producing polypeptide
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United States of America Patent
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Jun 6, 2017
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Apr 27, 2012
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Apr 29, 2011
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Abstract
The present disclosure relates to methods of decreasing lactate production in cell culture using divalent transitional metallic salts. The present disclosure also relates to a method of producing polypeptide by adding divalent transitional metallic salt to the cell culture medium for reducing lactate accumulation followed by fermenting and recovering the polypeptide.
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