Fusion expression of G-protein coupled receptor

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United States of America Patent

PATENT NO 9670252
APP PUB NO 20150166609A1
SERIAL NO

14633153

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The present invention relates to fusion proteins for the expression of G-protein coupled receptor proteins (GPCR) with the fusion partners, as inserted fragments, from mammalian cells. The fusion partners are from a fragment of APJ protein (“the APJ protein fragment”) or a fragment with homology of more than 90% similarity to the APJ protein fragment; or a fragment of RGS16 protein (the “RGS16 protein fragment”) or a fragment with homology of more than 90% similarity to the RGS16 protein fragment; or the fragment of DNJ protein (the “DNJ protein fragment”) or a fragment with homology of more than 90% similarity to DNJ protein fragment. The fusion expression of GPCR with the above mentioned fusion partners can improve the protein yield and stability when purified from cells. Therefore, these fusion protein partners can be widely used for the study of GPCR proteins.

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VIVA BIOTECH (SHANGHAI) LTD2ND FLOOR BUILDING 2 NO 50 LANE 63 FARADAY ROAD CHINA (SHANGHAI) PILOT FREE TRADE ZONE PUDONG NEW AREA SHANGHAI 201210 SHANGHAI CITY SHANGHAI CITY 201210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cai, Jianhua Shanghai, CN 6 0
Han, Min Shanghai, CN 31 69
Jiang, Fan Shanghai, CN 94 1035
Li, Na Shanghai, CN 361 1146
Mao, Chen Shanghai, CN 45 346
Ren, Delin Shanghai, CN 4 0
Shen, Jian Shanghai, CN 161 1375
Su, Xiaoyan Shanghai, CN 14 85
Wei, Wentao Shanghai, CN 6 7
Zeng, Xiuhong Shanghai, CN 4 0

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