Universal sample preparation system and use in an integrated analysis system

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9663819
APP PUB NO 20150136602A1
SERIAL NO

14552389

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Abstract

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The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

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Patent Owner(s)

Patent OwnerAddress
INTEGENX INC6055 SUNOL BLVD PLEASANTON CA 94566

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
El-Sissi, Omar Fremont, US 9 636
Jovanovich, Stevan B Livermore, US 42 2706
Nielsen, William D San Jose, US 36 1368
Van, Gelder Ezra Palo Alto, US 30 2027
Vangbo, Mattias Fremont, US 27 1084

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