Modified oligonucleotides for telomerase inhibition
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United States of America Patent
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May 23, 2017
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app pub date -
May 18, 2015
filing date -
Sep 9, 2003
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Abstract
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
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