Method for suppressing teratoma formation via selective cell death induction in undifferentiated human-induced pluripotent stem cells

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United States of America Patent

PATENT NO 9657273
SERIAL NO

14434873

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Abstract

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The present invention relates to a method for preparing differentiated cells derived from induced pluripotent stem cell, wherein undifferentiated induced pluripotent stem cells (iPS) are removed, the method comprising steps of: (a) preparing a cell sample including undifferentiated induced pluripotent stem cells and differentiated cells by differentiating induced pluripotent stem cells; and (b) causing selective apoptosis of the undifferentiated induced pluripotent stem cells by treating the resultant in step (a) with quercetin of Formula 1 below or with YM-155 of Formula 2 below.

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Patent Owner(s)

Patent OwnerAddress
THE MCLEAN HOSPITAL CORPORATION115 MILL STREET BELMONT MA 02487

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cha, Hyuk Jin Seoul, KR 6 8
Kim, Kwang Soo Lexington, US 229 1487

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