Method for synthesizing key intermediate of apixaban

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United States of America Patent

PATENT NO 9656958
APP PUB NO 20160280646A1
SERIAL NO

14902286

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Abstract

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The invention relates to a method for synthesizing an intermediate of Apixaban comprising reacting a compound of formula I with 5-chloro-valeryl chloride in the presence of inorganic base in an inert solvent to obtain a compound of formula II, with the reaction formula of (A), wherein R is selected from nitro group and the group (B). The method is mild in reaction condition, simple in operation, easy in purification, inexpensive in production cost, environmental-friendly, and suitable for industrial production.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG HUAHAI PHARMACEUTICAL CO LTD317024 FLOOD BRIDGE LINHAI CITY TAIZHOU CITY ZHEJIANG PROVINCE TAIZHOU CITY ZHEJIANG PROVINCE 317024
SHANGHAI SYNCORES TECHNOLOGIES INC LTDNO 538 CAILUN ROAD ZHANGJIANG HI-TECH PARK PUDONG NEW DISTRICT SHANGHAI 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Luning Shanghai, CN 21 11
Wang, Boyu Shanghai, CN 26 39
Yao, Jinfeng Shanghai, CN 2 5
Zhang, Jeannie Shanghai, CN 2 0

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