Prodrug using nitroimidazole
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United States of America Patent
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May 23, 2017
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app pub date -
Feb 13, 2013
filing date -
Feb 13, 2012
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Abstract
Provided is a prodrug of 2-nitro-1-imidazolepropionic acid and a therapeutically active organic compound having on the molecule an amino group, a cyclic amino group or a hydroxyl group, particularly a prodrug in which the therapeutically active organic compound is selected from among antitumor agents. The prodrug cleaves specifically under hypoxic conditions in vivo to exhibit the inherent therapeutic activity.
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