Platinum (II) compound, preparation method therefor, and pharmaceutical composition and application thereof

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United States of America Patent

PATENT NO 9650403
SERIAL NO

14897979

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Abstract

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Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY200040 NO 1320 WEST BEIJING ROAD SHANGHAI SHANGHAI CITY SHANGHAI CITY 200040
CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRYSHANGHAI 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hu, Haifeng Shanghai, CN 68 611
Lin, Jun Shanghai, CN 171 1539
Liu, Quanhai Shanghai, CN 13 13
Shu, Yongzhi Shanghai, CN 6 7
Zhou, Bin Shanghai, CN 272 904
Zhu, Baoquan Shanghai, CN 2 1

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