Structured peptide processing
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United States of America Patent
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May 9, 2017
Grant Date -
Feb 18, 2016
app pub date -
Apr 1, 2014
filing date -
Feb 4, 2009
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Abstract
The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more proteases; and sorting the ligands according to the extent of proteolytic cleavage.
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