Factor D inhibitors useful for treating inflammatory disorders

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United States of America Patent

PATENT NO 9643986
SERIAL NO

14630959

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Abstract

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Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

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Patent Owner(s)

Patent OwnerAddress
ACHILLION PHARMACEUTICALS INC300 GEORGE ST NEW HAVEN CT 06511

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deshpande, Milind Madison, US 99 2289
Wiles, Jason Allan Madison, US 102 2022

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