Compositions for rapidly treating severe hypoglycemia

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United States of America Patent

PATENT NO 9642894
SERIAL NO

14676415

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Abstract

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Disclosed is a composition for parenteral administration comprising a glucagon peptide which has been dried in a non-volatile glycine buffer, and wherein the glucagon peptide has a pH memory that is about equal to the pH of the glucagon peptide in the non-volatile buffer, wherein the pH memory is between 2.5 to 3.5, an aprotic polar solvent, wherein the peptide is solubilized in the aprotic polar solvent, and wherein the aprotic polar solvent is dimethyl sulfoxide (DMSO), trehalose, glycine, and optionally hydrochloric acid, wherein the moisture content of the composition is less than 5 wt. %.

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Patent Owner(s)

Patent OwnerAddress
XERIS PHARMACEUTICALS INC1375 WEST FULTON STREET SUITE 1300 CHICAGO IL 60607

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Prestrelski, Steven J San Diego, US 29 1016

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