Digital sequence analysis of DNA methylation
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United States of America Patent
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May 2, 2017
Grant Date -
Aug 2, 2012
app pub date -
Feb 2, 2012
filing date -
Feb 2, 2011
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Abstract
The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
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