Reagent for diagnosing tumor, pharmaceutical composition, and screening method
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United States of America Patent
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Apr 25, 2017
Grant Date -
Jan 7, 2016
app pub date -
Jul 9, 2015
filing date -
Dec 12, 2012
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Abstract
The present invention provides antibodies useful for diagnosing and treating tumors as well as methods of screening for antitumor agents. More specifically, tumors can be diagnosed and treated using an anti-phosphorylated p62 antibody that recognizes phosphorylation of serine at position 351 of an amino acid sequence of SEQ ID No. 1 or at a position corresponding thereto. An antitumor agent can be obtained by screening for a substance that inhibits the phosphorylation or that dephosphorylates the phosphorylated serine.
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