Method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof
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United States of America Patent
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Apr 25, 2017
Grant Date -
Jul 17, 2014
app pub date -
Apr 27, 2012
filing date -
Apr 29, 2011
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Abstract
The present disclosure relates to a method of reducing heterogeneity in antibodies during culturing, wherein the heterogeneity is due to proportion of charge variant of the antibody. The disclosure also comprises a process of growing cells in a cell culture system that results in antibodies with the reduced heterogeneity. In one embodiment antibody heterogeneity is reduced by the addition of divalent transitional metal ions such as zinc (Zn2+) to the cell culture medium. In another embodiment antibody heterogeneity is reduced by decreasing the osmolality of the cell culture medium.
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