Multispecific antigens binding fragments and multispecific antibodies derived therefrom comprising mutant CH1 and CL-κ domains

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United States of America Patent

PATENT NO 9631031
SERIAL NO

14130773

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Abstract

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The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy/light chain mispairing.

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Patent Owner(s)

Patent OwnerAddress
AZIENDA SOCIO SANITARIA TERRITORIALE PAPA GIOVANNI XXIIIPIAZZA OMS 1 BERGAMO 24127

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cerutti, Martine Saint-christol-lez-ales, FR 18 335
Choblet, Sylvie Ales, FR 4 17
Golay, Josee Bergamo, IT 5 21
Iwaszkiewicz, Justyna Geneva, CH 5 17
Kadouche, Jean Paris, FR 15 52
Mach, Jean-Pierre Bellevue, CH 16 213
Michielin, Olivier Lausanne, CH 8 18
Zoete, Vincent Morges, CH 16 27

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