Human monoclonal antibodies to fucosyl-GM1 and methods for using anti-fucosyl-GM1 antibodies
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United States of America Patent
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Apr 25, 2017
Grant Date -
Jan 28, 2016
app pub date -
Aug 13, 2015
filing date -
Dec 8, 2005
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Abstract
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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