Method and reagent for diagnosis and/or evaluation of progression of graft-versus-host disease
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United States of America Patent
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Apr 25, 2017
Grant Date -
Aug 21, 2014
app pub date -
Apr 3, 2014
filing date -
Jun 22, 2007
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Abstract
Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody.
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