Dipeptide analogs for treating conditions associated with amyloid fibril formation
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United States of America Patent
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Apr 25, 2017
Grant Date -
Nov 12, 2015
app pub date -
Jul 22, 2015
filing date -
Nov 15, 2010
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Abstract
Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
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