Process for the preparation of nepafenac
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United States of America Patent
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Apr 25, 2017
Grant Date -
Jul 28, 2016
app pub date -
Jun 26, 2014
filing date -
Jun 27, 2013
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Abstract
Described herein are processes for the preparation of nepafenac and related intermediates, particularly wherein 2-aminobenzophenone is treated with a 2-(alkylthio)acetamide in the presence of sulfuryl chloride to afford a 2-(2-amino-3-benzoyl-phenyl)-2-(alkylthio)acetamide, which upon reduction affords nepafenac. Described herein are also processes for the purification of nepafenac, particularly for the removal of structurally similar impurities.
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