Methods and compositions for use of neutrophil elastase and proteinase 3 as diagnostic biomarkers
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United States of America Patent
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Apr 18, 2017
Grant Date -
Dec 3, 2015
app pub date -
May 29, 2015
filing date -
May 30, 2014
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Abstract
Methods and compositions for identifying autoimmune diabetes are provided. One aspect provides a method for the evaluation of risk and progression of autoimmune diabetes in mammalian subjects. The method includes measuring the enzymatic activities and/or protein concentrations of neutrophil elastase and proteinase 3 in a subject and comparing the measured levels of these proteases to respective reference levels.
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