Combination of biomarkers for the detection and evaluation of hepatitis fibrosis

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United States of America Patent

PATENT NO 9624541
SERIAL NO

13984702

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Abstract

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The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being:

    SPP1, andat least one gene from among A2M and VIM, andat least one gene from among IL8, CXCL10 and ENG, andoptionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.

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Patent Owner(s)

Patent OwnerAddress
BIO-RAD EUROPE GMBHHOLBEINSTRASSE 75 BASEL 4051

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Afshar, Mohammad Paris, FR 11 69
Asselah, Tarik Paris, FR 8 39
Batxelli, Isabelle Catherine Aigues-Vives, FR 8 36
Bieche, Ivan Suresnes, FR 8 33
Jullian, Nathalie Montrouge, FR 5 25
Laune, Daniel Grabels, FR 5 22
Marcellin, Patrick Paris, FR 8 42
Mathieu, Eve Laure Montpellier, FR 5 25
Vidaud, Michel Fontenay Sous Bois, FR 9 36
Watelet, Bénédicte Saint Clement de Riviere, FR 6 29

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