Lowered affinity antibodies and methods of making the same
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United States of America Patent
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Apr 18, 2017
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app pub date -
Jan 28, 2011
filing date -
Jan 28, 2010
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Abstract
The present invention provides methods for making novel, rationally designed lowered affinity antibodies. The methods of the present invention make antibodies that have variable domains that have been designed to reduce or eliminate the antigen binding activity of the parental antibody without altering the overall (3) dimensional antibody structure. Using the antibodies made using methods of the present invention in various assays allows researchers to distinguish effects that result from specific antigen-antibody interactions from other, non-specific antibody effects.
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