Bone implant materials comprising cross-linked bioactive hydrogel matrices
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United States of America Patent
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Apr 18, 2017
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app pub date -
Jan 30, 2015
filing date -
Feb 21, 2002
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Abstract
The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- A01N:PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLA....
- A61F:FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES....
- B29C:SHAPING OR JOINING OF PLASTICS; SHAPING OF SUBSTAN....
- B29L:INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RE....
- A61L:METHODS OR APPARATUS FOR STERILISING MATERIALS OR ....
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