Downregulation of SINE/ALU retrotransposon transcription to induce or restore proliferative capacity and/or pluripotency to a stem cell
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United States of America Patent
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Apr 11, 2017
Grant Date -
Dec 26, 2013
app pub date -
Oct 20, 2011
filing date -
Oct 26, 2010
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Abstract
In certain embodiments methods are provided for inducing and/or restoring and/or maintaining a non-senescent phenotype, or aspects thereof (e.g., proliferative capacity and/or pluripotency) in a mammalian cell. The methods typically involve reducing the level or activity of SINE/Alu retrotransposon transcripts in the cell in an amount sufficient to induce or restore proliferative capacity and/or pluripotency to said mammalian cell.
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