Taxane analogs for the treatment of brain cancer
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United States of America Patent
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Apr 11, 2017
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Sep 11, 2015
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Feb 28, 2007
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Abstract
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.
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