Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof
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United States of America Patent
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Apr 4, 2017
Grant Date -
Nov 21, 2013
app pub date -
May 20, 2013
filing date -
May 11, 2009
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Abstract
Described are binding molecules, e.g., human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, e.g., H3N2, and have a broad neutralizing activity against such influenza virus. Described are polynucleotides encoding the binding molecules, their sequences and compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis, and/or treatment of influenza virus H3N2 infection. The binding molecules may provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.
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