Permeable glycosidase inhibitors and uses thereof
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United States of America Patent
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Apr 4, 2017
Grant Date -
Jun 4, 2015
app pub date -
May 3, 2013
filing date -
May 8, 2012
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Abstract
The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.
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