Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use

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United States of America Patent

PATENT NO 9611261
APP PUB NO 20160280695A1
SERIAL NO

14932787

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Abstract

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The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:

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Patent Owner(s)

Patent OwnerAddress
AMGEN INCTHOUSAND OAKS CALIFORNIA 91320-1799

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allen, Jennifer R Newbury Park, US 57 505
Amegadzie, Albert Moorpark, US 29 418
Brown, James Moorpark, US 221 2543
Frohn, Michael J Thousand Oaks, US 46 387
Guzman-Perez, Angel Belmont, US 41 230
Harrington, Paul E Camarillo, US 23 202
Lopez, Patricia Woodland Hills, US 69 1004
Low, Jonathan D Reseda, US 31 393
Ma, Vu Van Oak Park, US 33 488
Minatti, Ana Elena Santa Monica, US 41 467
Nishimura, Nobuko West Hills, US 58 912
Qian, Wenyuan Newbury Park, US 58 271
Rumfelt, Shannon Camarillo, US 24 366
Rzasa, Robert M Ventura, US 45 717
Sham, Kelvin Thousand Oaks, US 15 281
Smith, Adrian L Simi Valley, US 17 498
White, Ryan Somerville, US 76 1315
Xue, Qiufen Newbury Park, US 28 378

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