Fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof for preventing and treating rheumatoid arthritis
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United States of America Patent
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Mar 28, 2017
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May 29, 2014
app pub date -
May 31, 2013
filing date -
Dec 2, 2010
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Abstract
The present invention relates to a fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof. More specifically, the present invention relates to a fusion peptide, comprising a) a dhFas-1 domain which is the fourth fas-1 domain of βig-h3 lacking H1 and H2 regions; b) a MMP (Matrix metalloproteinase) substrate; and c) a peptide comprising RGD motif and an use thereof for preventing and treating inflammatory disease. The fusion peptide of the present invention inhibits expension of rheumatoid arthritis by adhesion and migration of sinoviocytes and may be used for preventing or treating inflammatory disease by inhibiting infiltration of immune cells.
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