Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family
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United States of America Patent
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Mar 28, 2017
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Oct 2, 2014
app pub date -
Jul 6, 2012
filing date -
Jul 8, 2011
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Abstract
Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.
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