Side-chain protected oligopeptide fragment condensation using subtilisins in organic solvents

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United States of America Patent

PATENT NO 9598714
APP PUB NO 20150037840A1
SERIAL NO

14379789

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Abstract

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Method for enzymatically synthesizing an oligopeptide, comprising the coupling of an (optionally N-protected) protected oligopeptide ester with an (optionally C-protected) protected oligopeptide nucleophile in an organic solvent or an organic solvent mixture having a water content of 0.1 vol % or less, by a subtilisin in any possible form.

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Patent Owner(s)

Patent OwnerAddress
FRESENIUS KABI IPSUM S R LVIA ROMA 108 CASSINA DE' PECCHI - MILANO 20060

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nuijens, Timo Geleen, NL 11 14
Quaedflieg, Peter Jan Leonard Mario Geleen, NL 24 33

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