Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
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United States of America Patent
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Mar 21, 2017
Grant Date -
Apr 17, 2014
app pub date -
Mar 12, 2012
filing date -
Mar 11, 2011
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Abstract
An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.
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