Targeted therapeutics

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United States of America Patent

PATENT NO 9597343
APP PUB NO 20150139905A1
SERIAL NO

14510518

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Abstract

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The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

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Patent Owner(s)

Patent OwnerAddress
MADRIGAL PHARMACEUTICALS INC200 BARR HARBOR DRIVE SUITE 200 WEST CONSHOHOCKEN PA 19428

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chimmanamada, Dinesh U Arlington, US 52 975
Ying, Weiwen Lexington, US 100 1571

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