Compounds and compositions for modulating EGFR mutant kinase activities
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United States of America Patent
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Mar 14, 2017
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Apr 14, 2016
app pub date -
Oct 13, 2015
filing date -
Oct 13, 2014
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Abstract
The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer and immune disease. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefore. The invention also provides useful intermediates generated during the syntheses of the aminopyrimidine derivatives.
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