Process for the preparation of gamma amino acids and intermediates used in said process
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United States of America Patent
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Mar 14, 2017
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Nov 13, 2014
app pub date -
Nov 22, 2012
filing date -
Nov 22, 2011
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Abstract
The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.
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