Methods and compositions related to thioesterase enzymes

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United States of America Patent

PATENT NO 9587231
SERIAL NO

14826657

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Abstract

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The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

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Patent Owner(s)

Patent OwnerAddress
GENOMATICA INC4757 NEXUS CENTER DRIVE SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alibhai, Murtaza Austin, US 7 207
Arlagadda, Vikranth South San Francisco, US 25 80
Clarke, Elizabeth South San Francisco, US 12 50
Groban, Eli South San Francisco, US 6 43
Hom, Louis South San Francisco, US 15 253
Hu, Zhihao South San Francisco, US 77 835
Trinh, Na Burlingame, US 18 153

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  • 26 Citation Count
  • C07H Class
  • 97.37 % this patent is cited more than
  • 8 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges233015571505030106334301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 90100 +0200400600800100012001400160018002000220024002600

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