Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
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United States of America Patent
Stats
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Mar 7, 2017
Grant Date -
Jul 4, 2013
app pub date -
Jul 8, 2011
filing date -
Jul 9, 2010
priority date (Note) -
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Abstract
The invention relates to compounds of general formula (I) wherein R1, R2, R3, R4, m and n are defined as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immuno-suppression would be desirable for example in organ transplantation.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
LEO PHARMA A/S | 2750 BALLERUP |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Greve, Daniel R | Stenløse, DK | 3 | 6 |
# of filed Patents : 3 Total Citations : 6 | |||
Grue-Sørensen, Gunnar | Roskilde, DK | 9 | 24 |
# of filed Patents : 9 Total Citations : 24 | |||
Nielsen, Simon Felbdæk | Herlev, DK | 1 | 0 |
# of filed Patents : 1 Total Citations : 0 | |||
Ryttersgaard, Carsten | Roskilde, DK | 5 | 5 |
# of filed Patents : 5 Total Citations : 5 | |||
Sams, Anette Graven | Værløse, DK | 26 | 70 |
# of filed Patents : 26 Total Citations : 70 | |||
Schou, Søren Christian | Roskilde, DK | 7 | 8 |
# of filed Patents : 7 Total Citations : 8 |
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