Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

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United States of America Patent

PATENT NO 9586961
APP PUB NO 20130172325A1
SERIAL NO

13809059

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Abstract

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The invention relates to compounds of general formula (I) wherein R1, R2, R3, R4, m and n are defined as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immuno-suppression would be desirable for example in organ transplantation.

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LEO PHARMA A/S2750 BALLERUP

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Greve, Daniel R Stenløse, DK 3 6
Grue-Sørensen, Gunnar Roskilde, DK 9 24
Nielsen, Simon Felbdæk Herlev, DK 1 0
Ryttersgaard, Carsten Roskilde, DK 5 5
Sams, Anette Graven Værløse, DK 26 70
Schou, Søren Christian Roskilde, DK 7 8

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges763281956782001332911183139501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +050010001500200025003000350040004500500055006000650070007500800085009000

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